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Mio Fertility › Station IV · Signs
Male factor

Male factor infertility
Half the equation is his.

Short answer

Male factor is diagnosed in roughly 30% of infertility cases, and in another 20% the factor is combined. It breaks down into four types, identified through the semen analysis. Treatment ranges from correcting reversible causes, targeted supplementation and lifestyle changes to assisted reproduction (IUI, IVF, ICSI) in more severe cases.

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Built on ESHRE · ASRM · NICE · CDC guidelinesReferences in every chapter
The four types

What the words on the report mean

DiagnosisWhat it meansRelated WHO reference value
OligospermiaLow sperm concentrationConcentration ≥ 16 million/mL
AsthenospermiaLow motilityProgressive motility ≥ 30%
TeratospermiaA high proportion of abnormally shaped spermNormal morphology ≥ 4%
AzoospermiaNo sperm in the ejaculateNot applicable

Reference values: WHO laboratory manual for the examination and processing of human semen, 6th ed., 2021.

For the result to mean something, the test has to be done correctly: 3 to 5 days of sexual abstinence beforehand, no fever in the past 2 weeks, no recent antibiotics, collection at the lab and no lubricants.

An abnormal result is not a verdict

If a result comes back below the reference, do not assume “male infertility”. Sperm production varies month to month. The clinical standard is to repeat the test in 4 to 12 weeks before drawing conclusions and, in parallel, to change habits. Many men with a bad first test come back normal after 3 to 6 months of adjustments.

Treatment

From habits to ICSI

Unlike eggs, which are finite, sperm is produced continuously, and habit changes show a measurable effect in about 90 days. The treatment options the book lists:

  • Treating reversible causes, such as varicocele or hormones.
  • Targeted supplementation, for at least 90 days.
  • Lifestyle changes: quitting smoking (vapes included), cutting back on alcohol, avoiding scrotal heat, sleeping well, keeping a healthy weight.
  • Assisted reproduction in more severe cases: IUI (mild male factor is one of its indications), IVF or ICSI, in which a single sperm is injected directly into each egg. Severe male factor is the classic indication for ICSI.
  • Donor sperm, in cases of azoospermia with no possibility of extraction.
When to see a urologist

Signs that call for a specialist

If the semen analysis is abnormal on two evaluations 4 to 12 weeks apart, or if there are specific risk factors, the couple needs to see a urologist, ideally one who specializes in reproduction. The risk factors the book lists:

  • An undescended testicle in childhood (cryptorchidism)
  • Mumps after puberty
  • Previous inguinal or testicular surgery
  • A palpable varicocele
  • Significant testicular trauma
  • Past or current use of anabolic steroids (recovery takes 6 to 24 months after stopping)
  • Previous chemotherapy or radiation therapy

Male factor and a female diagnosis can also exist at the same time: PCOS plus male factor is the book's example. That is why the book puts the semen analysis in the very first month of the workup, alongside your own tests.

Where this fits

This is one chapter. The map has 42.

Male factor is diagnosis number 3 in Chapter 33 of Map to the Positive, in Station IV (Signs). His side of the map is covered in full in Station III (Optimization): how to do the semen analysis correctly, the WHO reference values, the 10 habits with proven impact in 90 days and the male supplement stack. Station IV adds the red flags in his history and when to see a urologist.

IFoundation
IIAttunement
IIIOptimization
IVSigns
VPositive
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References: WHO laboratory manual for the examination and processing of human semen, 6th ed., 2021.

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